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Considering mechanisms underlying OAs-assisted metal-chelation, OAs confer metal-tolerance by transporting metals through the xylem and sequestrating ions in the vacuole, but they have multiple additional roles in the cell (reviewed by Fernie and Martinoia, 2009

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As such, I will primarily focus on this literature in the remainder of my discussion of Agm

Alcoholic liver disease: Chronic alcohol consumption severely depletes hepatic glutathione through multiple mechanisms: increased ROS production during ethanol metabolism, reduced cysteine availability, and impaired mitochondrial glutathione transport